General
Preferred name
Batoprotafib
Synonyms
TNO155 ()
Tno 155 ()
Ptpn11 inhibitor tno155 ()
TNO-155 ()
Shp2 inhibitor tno155 ()
P&D ID
PD143487
CAS
1801765-04-7
Tags
available
probe
drug candidate
Drug Status
investigational
Max Phase
2.0
Drug indication
Neoplasm
Probe info
Probe type
experimental probe
Probe sources
Chemical Probes.org
High-quality chemical probes
Probe targets
Structure
Probe scores
P&D probe-likeness score
[[ v.score ]]%
Structure formats
[[ format ]]
[[ compound[format === 'MOL' ? 'molblock' : format.toLowerCase()] ]]
Description
(extracted from source data)
DESCRIPTION Batoprotafib (TNO155) is a potent selective and orally active allosteric inhibitor of wild-type SHP2 (IC50=0.011 ¦ÌM). Batoprotafib has the potential for the study of RTK-dependent malignancies, especially advanced solid tumors[1].
PRICE 288
DESCRIPTION TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 ??M),with potential antineoplastic activity.
DESCRIPTION TNO155 is an oral, allosteric inhibitor of SHP2 (a nonreceptor protein tyrosine phosphatase that's encoded by the PTPN11 gene) . SHP2 is an oncoprotein in its own right, but its inhibition is also being exploited to combat tumours that are driven by hyperactivation in the RAS-RAF-ERK signalling pathway.
We matched TNO155's chemical structure to the INN 'batoprotafib' which was published in the WHO's proposed INN list 127 on 21 July 2022. (GtoPdb)
MOA Inhibitor (Chemical Probes.org)
DESCRIPTION TNO155 is a protein tyrosine phosphatase (PTP) non-receptor type 11 (SHP2; src homology region 2 domain phosphatase; PTPN11) inhibitor(IC50 : 0.011 μM),with potential antineoplastic activity. (TargetMol Bioactive Compound Library)
Cell lines
5
Organisms
0
Compound Sets
10
Cayman Chemical Bioactives
32525
ChEMBL Drugs
CHEMBL4650521
Chemical Probes.org
tno155
CZ-OPENSCREEN Bioactive Library
DrugBank
DB19137
Guide to Pharmacology
12068
High-quality chemical probes
PD143487
MedChem Express Bioactive Compound Library
HY-136173
Selleckchem Bioactive Compound Library
tno155
TargetMol Bioactive Compound Library
T13176
External IDs
16
Properties
(calculated by RDKit )
Molecular Weight
421.15
Hydrogen Bond Acceptors
9
Hydrogen Bond Donors
3
Rotatable Bonds
3
Ring Count
4
Aromatic Ring Count
2
cLogP
2.17
TPSA
129.2
Fraction CSP3
0.5
Chiral centers
2.0
Largest ring
6.0
QED
0.68
Structural alerts
0
No structural alerts detected
Custom attributes
(extracted from source data)
Target
phosphatase
SHP-2
SHP2
PTPN11
Pathway
Metabolic Enzyme/Protease
Protein Tyrosine Kinase/RTK
Metabolism
Target class
Enzyme
Target subclass
Protein-tyrosine phosphatase
Control
CANSAR3148275
Source data